Residual endogenous corticosteroid production in patients with adrenal insufficiency.

ABSTRACT:

Objective

This study aimed at comparing precursors of endogenous corticosteroid production in patients with primary adrenal insufficiency and in secondary adrenal insufficiency.

Design

Twenty patients with primary adrenal insufficiency and matched controls and 19 patients with secondary adrenal insufficiency participated in this ancillary analysis of two different studies.

Patients and measurements

Patients with primary adrenal insufficiency were on stable hydrocortisone and fludrocortisone therapy. Patients with secondary adrenal insufficiency received two different doses of hydrocortisone in a randomized crossover study. Main outcome measures were concentrations of precursors of cortisol and aldosterone measured by LC-MS/MS RESULTS: Compared to controls, progressive

SUBMITTER: Vulto A 

PROVIDER: S-EPMC6851705 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature