Personalizing Decision-Making for Patients Choosing Contralateral Prophylactic Mastectomy: A Utility Analysis of Genetic Factors and the Relative Risk of Breast Cancer.

ABSTRACT:

Introduction

There has been an increasing trend of patients with breast cancer electing to undergo contralateral prophylactic mastectomy (CPM), despite the lack of evidence showing long-term survival benefit. We aim to quantify the tiered amount of genetic and surgical complication risk deemed necessary to justify CPM.

Methods

A review of breast cancer-affiliated genetic mutations and morbidity rates of breast cancer surgery from a single institution was compiled. A survey using a utility analysis was created. Severity of breast cancer genetic risk and morbidity risk warranting CPM was quantified and evaluated.

Results

A total of 143 surveys were submitted by women of the general population. Data analysis confirmed previous predictions that at a hypothetical increased

SUBMITTER: Campwala I 

PROVIDER: S-EPMC6851731 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature