Defining a novel subset of CD1d-dependent type II natural killer T cells using natural killer cell-associated markers.

ABSTRACT: Natural killer T (NKT) cells are αβ T cell receptor (TCR) expressing innate-like T cells that display natural killer (NK) cell markers. Based on TCR characteristics, they are divided into two groups restricted to the MHC class I-like molecule CD1d. Type I NKT cells, most extensively studied, are identified by a semi-invariant Vα14-Jα18 (mouse, Vα24-Jα18 in humans) TCR reactive to the prototypic ligand α-galactosylceramide presented on CD1d. In contrast, type II NKT cells display diverse TCR reacting to different CD1d-presented ligands. There are no reagents that identify all type II NKT cells, limiting their exploration. Here, we searched for novel type II NKT cells by comparing Jα18^-/- MHCII^-/- mice that harbour type II but not type I NKT cells, and CD1d^-/-

SUBMITTER: Singh AK 

PROVIDER: S-EPMC6851763 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature