Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification.

ABSTRACT: Multiple mode of action (MOA) frameworks have been developed in aquatic ecotoxicology, mainly based on fish toxicity. These frameworks provide information on a key determinant of chemical toxicity, but the MOA categories and level of specificity remain unique to each of the classification schemes. The present study aimed to develop a consensus MOA assignment within EnviroTox, a curated in vivo aquatic toxicity database, based on the following MOA classification schemes: Verhaar (modified) framework, Assessment Tool for Evaluating Risk, Toxicity Estimation Software Tool, and OASIS. The MOA classifications from each scheme were first collapsed into one of 3 categories: non-specifically acting (i.e., narcosis), specifically acting, or nonclassifiable. Consensus rules were developed based on t

SUBMITTER: Kienzler A 

PROVIDER: S-EPMC6851772 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature