Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.

ABSTRACT: The fast and reliable propagation of action potentials along myelinated fibers relies on the clustering of voltage-gated sodium channels at nodes of Ranvier. Axo-glial communication is required for assembly of nodal proteins in the central nervous system, yet the underlying mechanisms remain poorly understood. Oligodendrocytes are known to support node of Ranvier assembly through paranodal junction formation. In addition, the formation of early nodal protein clusters (or prenodes) along axons prior to myelination has been reported, and can be induced by oligodendrocyte conditioned medium (OCM). Our recent work on cultured hippocampal neurons showed that OCM-induced prenodes are associated with an increased conduction velocity (Freeman et al., 2015). We here unravel the nature of the oligod

SUBMITTER: Dubessy AL 

PROVIDER: S-EPMC6851800 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature