Thrombin-generating potential, plasma clot formation, and clot lysis are impaired in patients with bleeding of unknown cause.

ABSTRACT:

Background

In a large proportion of patients with a mild to moderate bleeding tendency no diagnosis can be established (bleeding of unknown cause, BUC).

Objectives

To investigate possible dysfunctions in thrombin generation and plasma clot formation and lysis in patients with BUC from the Vienna Bleeding Biobank (VIBB).

Patients and methods

Thrombin generation and plasma clot properties of 382 BUC patients were compared to those of 100 healthy controls and 16 patients with factor VIII (FVIII) activity ≤50%.

Results

Thrombin generation was significantly impaired in BUC patients compared to healthy controls, exhibiting a prolonged lag time and time to peak and decreased maximum thrombin generation, velocity index, and area under the curve (AUC). The assessment of

SUBMITTER: Hofer S 

PROVIDER: S-EPMC6851858 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature