Physical Performance in Memory Clinic Patients: The Potential Role of the White Matter Network.

ABSTRACT:

Background/objectives

Memory clinic patients commonly also have declined physical performance. This may be attributable to white matter injury, due to vascular damage or neurodegeneration. Quantifying white matter injury is made possible by new magnetic resonance imaging (MRI) techniques, including diffusion-weighted imaging (DWI) of network connectivity. We investigated whether physical performance in memory clinic patients is related to white matter network connectivity.

Design

Observational cross-sectional study.

Setting

Memory clinic.

Participants

Patients referred to a memory clinic with vascular brain injury on MRI (n = 90; average age = 72 years; 60% male; 34% with diagnosis Alzheimer disease).

Measurements

We reconstructed structural brain networ

SUBMITTER: Verwer JH 

PROVIDER: S-EPMC6851861 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature