Observational evidence from patients diagnosed with chronic lymphocytic leukaemia (CLL) in Finland between 2005-2015 show improved survival over time.

ABSTRACT:

Objectives

We aimed to describe treatment patterns of chronic lymphocytic leukaemia (CLL) patients in routine practice settings, compare overall survival and time-to-next-treatment among patients treated in different time periods (2005-2008, 2009-2013, 2014-2015), and explore associated factors.

Methods

This retrospective cohort study included adult CLL patients from the Finnish Hematology Registry.

Results

In total, 124 and 64 CLL patients received first- and second-line treatments, respectively. The use of first- and second-line treatments with bendamustine-rituximab (BR) increased, while chlorambucil-based treatments decreased over time. Patients treated in more recent years showed a trend towards longer first- and second-line survival. A trend towards inferior ove

SUBMITTER: Lindstrom V 

PROVIDER: S-EPMC6851967 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature