Ageing significantly impacts the biomechanical function and structural composition of skin.

ABSTRACT: Skin ageing is a complex process involving the additive effects of skin's interaction with its external environment, predominantly chronic sun exposure, upon a background of time-dependent intrinsic ageing. Here, using non-invasive cutometry and ballistometry, we explore the consequences of ageing on the biomechanical function of skin in otherwise healthy White Northern European volunteers. Intrinsic skin ageing caused biomechanical decline; skin loses both resilience (P < 0.01) and elasticity (P < 0.001), which is characterised histologically by modest effacement of rete ridges (P < 0.05) and disorganisation of papillary dermal elastic fibres. At photoexposed sites, biomechanical testing identified significant loss of biomechanical function-particularly in the aged cohort. Photoaged forea

SUBMITTER: Langton AK 

PROVIDER: S-EPMC6851988 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature