Bio-derived hydroxystearic acid ameliorates skin age spots and conspicuous pores.

ABSTRACT:

Introduction

We report on the preparation and efficacy of 10-hydroxystearic acid (HSA) that improves facial age spots and conspicuous pores.

Methods

The hydration of oleic acid into HSA was catalyzed by the oleate hydratase from Escherichia coli. Following treatment with HSA, collagen type I and type III was assessed in primary human dermal fibroblasts together with collagen type III, p53 protein levels and sunburn cells (SBC) after UVB irradiation (1 J cm^-2 ) by immunohistochemistry on human ex vivo skin. UVB-induced expression of matrix metalloprotease-1 (MMP-1) was determined from full thickness skin by RT-qPCR. Modification of the fibroblast secretome by HSA was studied by mass-spectrometry-based proteomics. In a full-face, double blind, vehicle-controlled tri

SUBMITTER: Schutz R 

PROVIDER: S-EPMC6852045 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature