Decreased risk of HIV-associated TB during antiretroviral therapy expansion in rural Eswatini from 2009 to 2016: a cohort and population-based analysis.

ABSTRACT:

Objectives

This paper assesses patient- and population-level trends in TB notifications during rapid expansion of antiretroviral therapy in Eswatini which has an extremely high incidence of both TB and HIV.

Methods

Patient- and population-level predictors and rates of HIV-associated TB were examined in the Shiselweni region in Eswatini from 2009 to 2016. Annual population-level denominators obtained from projected census data and prevalence estimates obtained from population-based surveys were combined with individual-level TB treatment data. Patient- and population-level predictors of HIV-associated TB were assessed with multivariate logistic and multivariate negative binomial regression models.

Results

Of 11 328 TB cases, 71.4% were HIV co-infected and 51.8% were wo

SUBMITTER: Kerschberger B 

PROVIDER: S-EPMC6852273 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature