Burden of mild haemophilia A: Systematic literature review.

ABSTRACT:

Introduction

Although the clinical manifestations of severe haemophilia A (HA) are well studied, the challenges, if any, of living with mild HA are not clearly delineated to date.

Aim

To assess available evidence of clinical risks and societal/economic impacts of disease in adult patients with mild HA using a systematic literature review.

Methods

Prespecified study selection criteria were applied in a comprehensive literature search. Included studies varied in design and reported outcomes of interest for adults (≥13 years of age) with mild HA.

Results

Seventeen studies with a total of 3213 patients met eligibility criteria (published or presented in English, 1966-2017). Most studies were observational, and the outcomes reported were too sparse and dissimilar to

SUBMITTER: Peyvandi F 

PROVIDER: S-EPMC6852304 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature