Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barre syndrome: A living systematic review.

ABSTRACT: Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dim

SUBMITTER: Counotte MJ 

PROVIDER: S-EPMC6852328 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature