Increased gamma and decreased fast ripple connections of epileptic tissue: A high-frequency directed network approach.

ABSTRACT:

Objective

New insights into high-frequency electroencephalographic activity and network analysis provide potential tools to improve delineation of epileptic tissue and increase the chance of postoperative seizure freedom. Based on our observation of high-frequency oscillations "spreading outward" from the epileptic source, we hypothesize that measures of directed connectivity in the high-frequency range distinguish epileptic from healthy brain tissue.

Methods

We retrospectively selected refractory epilepsy patients with a malformation of cortical development or tumor World Health Organization grade I/II who underwent epilepsy surgery with intraoperative electrocorticography for tailoring the resection based on spikes. We assessed directed functional connectivity in the theta

SUBMITTER: Zweiphenning WJEM 

PROVIDER: S-EPMC6852371 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature