Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease.

ABSTRACT:

Background

Chemerin is an adipokine that signals through the G protein-coupled receptor ChemR23 and is associated with inflammation, glucose homeostasis, lipid metabolism and renal function, all of which strongly influence cardiovascular risk. However, elevated chemerin provides a survival advantage in patients with chronic kidney disease (CKD), but how this relates to the cardiovascular phenotype is unknown.

Objectives

The aim of the present study was to establish the association of chemerin with coronary calcification and to determine the effects of chemerin signalling, through ChemR23, in vascular smooth muscle cell (VSMC) calcification.

Methods

Plasma chemerin was measured in 113 patients with CKD and 50 healthy controls. All patients underwent computed tomography

SUBMITTER: Carracedo M 

PROVIDER: S-EPMC6852438 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature