Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model.

ABSTRACT:

Objective

This study was to inspect the antidepressant-like effect of prebiotics and probiotics, and to explore the effect of modulating gut microbiota on the serotonin (5-HT) metabolism.

Methods

Fifty rats were separated into control and other four groups randomly. The four groups underwent the chronic unpredictable mild stress (CUMS) intervention with or without prebiotics and probiotics (Bifidobacterium longum, L. rhamnosus) treatment. After weighted, the animals underwent a series of behavioral tests comprising the sucrose preference test (SPT) and the forced swimming test (FST). Central and colonic serotonin levels and relative metabolism factors were measured and analyzed. Microbiota was examined by 16S rRNA gene pyrosequencing.

Results

CUMS intervention caused

SUBMITTER: Li H 

PROVIDER: S-EPMC6852474 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature