Endogenous sex hormones and risk of venous thromboembolism in young women.

ABSTRACT:

Background

The risk of venous thromboembolism (VTE) in young women can predominantly be attributed to exogenous hormone use. The influence of (abnormalities in) endogenous sex hormones, as in polycystic ovary syndrome (PCOS) or primary ovarian insufficiency (POI), on VTE risk is uncertain.

Objectives

Th assess the association between endogenous sex hormone levels and VTE risk.

Methods

Women aged ≤45 years from the MEGA case-control study who provided a blood sample in the absence of exogenous hormone exposure or pregnancy were included. Sex hormone-binding globulin (SHBG), estradiol, follicle-stimulating hormone (FSH) and testosterone were measured. The free androgen index (FAI) and estradiol to testosterone ratio (E:T) were calculated. VTE risk was assessed according

SUBMITTER: Scheres LJJ 

PROVIDER: S-EPMC6852478 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature