Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG).

ABSTRACT:

Background and objectives

Gastrinomas are the most prevalent functioning neuroendocrine tumors (NET) in multiple endocrine neoplasia type 1 (MEN1). Guidelines suggest medical therapy in most patients, but surgery may be considered in a subgroup. Currently, factors to guide management are necessary. This population-based cohort study assessed prognostic factors of survival in patients with MEN1-related gastrinomas.

Methods

Patients with MEN1 having gastrinomas were identified in the Dutch MEN1 database from 1990 to 2014 based on fasting serum gastrin (FSG) levels and/or pathology. Predictors of overall survival were assessed using Cox regression.

Results

Sixty-three patients with gastrinoma (16% of the MEN1 population) were identified. Five- and 10-year overall surviva

SUBMITTER: van Beek DJ 

PROVIDER: S-EPMC6852496 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature