Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough.

ABSTRACT:

Background

Many cystic fibrosis (CF) patients chronically infected with Pseudomonas aeruginosa are on maintenance tobramycin inhalation therapy. Cough is reported as a side effect of tobramycin inhalation powder (TIP) in 48% of the patients. Objectives of this study were to investigate the association between the inspiratory flow of TIP and cough and to study the inhalation technique. We hypothesized that cough is related to a fast inhalation.

Materials and methods

In this prospective observational study, CF patients ≥ 6 years old on TIP maintenance therapy from four Dutch CF centers were visited twice at home. Video recordings were obtained and peak inspiratory flow (PIF) was recorded while patients inhaled TIP. Between the two home visits, the patients made three additiona

SUBMITTER: Meerburg JJ 

PROVIDER: S-EPMC6852538 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature