Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.

ABSTRACT:

Background

Studies using mouse models have revealed that mast cell progenitors are recruited from the blood circulation to the lung during acute allergic airway inflammation. The discovery of a corresponding human mast cell progenitor population in the blood has enabled to study the relation of circulating mast cell progenitors in clinical settings.

Objectives

To explore the possible association between the frequency of mast cell progenitors in the blood circulation and allergic asthma, we assessed the relation of this recently identified cell population with asthma outcomes and inflammatory mediators in allergic asthmatic patients and controls.

Methods

Blood samples were obtained, and spirometry was performed on 38 well-controlled allergic asthmatic patients and 29 c

SUBMITTER: Salomonsson M 

PROVIDER: S-EPMC6852573 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature