Dataset Information

The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

ABSTRACT:

Background

Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD.

Methods

Sputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment. AcPGP was isolated using solid phase extraction and measured by mass spectrometry. Demographics, spirometry, quality of life questionnaires, and quantitative computed tomography (CT) imaging with parametric response mapping (PRM) were obtained at baseline. Severe COPD exacerbations were recorded at 1-year of prospective follow-up. We used linear and logistic regression models to measure associations between AcPGP and features of COPD, and Kaplan-Meier analyses to measure time-to-first severe exacerbation.

Results

The 182 COPD participants in the analysis were 66 ± 8 years old, 62% male, 84% White race, and 39% were current smokers. AcPGP concentrations were 0.61 ± 1.89 ng/mL (mean ± SD) in sputum and 0.60 ± 1.13 ng/mL in plasma. In adjusted linear regression models, sputum AcPGP was associated with FEV₁/FVC, spirometric GOLD stage, PRM-small airways disease, and PRM-emphysema. Sputum AcPGP also correlated with severe AECOPD, and elevated sputum AcPGP was associated with shorter time-to-first severe COPD exacerbation. In contrast, plasma AcPGP was not associated with symptoms, pulmonary function, or severe exacerbation risk.

Conclusions

In COPD, sputum but not plasma AcPGP concentrations are associated with the severity of airflow limitation, small airways disease, emphysema, and risk for severe AECOPD at 1-year of follow-up.

Trial registration

ClinicalTrials.gov: NCT01969344 (SPIROMICS).

SUBMITTER: Wells JM

PROVIDER: S-EPMC6852714 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

Wells J Michael JM Xing Dongqi D Viera Liliana L Burkes Robert M RM Wu Yixin Y Bhatt Surya P SP Dransfield Mark T MT Couper David J DJ O'Neal Wanda W Hoffman Eric A EA Gaggar Amit A Barjaktarevic Igor I Curtis Jeffrey L JL Labaki Wassim W WW Han Mei Lan K MLK Freeman Christine M CM Putcha Nirupama N Schlange Thomas T Blalock J Edwin JE

Respiratory research 20191112 1

<h4>Background</h4>Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD.<h4>Methods</h4>Sputum and plasma samples were obtained from COPD participants in the ...[more]

PMID: 31718676

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Dataset Information

The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

Background

Methods

Results

Conclusions

Trial registration

Publications

The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

Similar Datasets

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