The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

ABSTRACT:

Background

Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD.

Methods

Sputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment. AcPGP was isolated using solid phase extraction and measured by mass spectrometry. Demographics, spirometry, quality of life questionnaires, and quantitative computed tomography (CT) imaging with parametric response mapping (PRM) were obtained at baseline. Severe COPD

SUBMITTER: Wells JM 

PROVIDER: S-EPMC6852714 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature