Influence of oxytocin receptor single nucleotide sequence variants on contractility of human myometrium: an in vitro functional study.

ABSTRACT:

Background

Oxytocin receptor (OXTR) gene variants have been shown to affect the prevalence of preterm birth, mode of delivery and oxytocin (OXT) requirements for labor induction and augmentation. We hypothesized that this might be associated with different myometrium responses to oxytocin. Our aim was to investigate the influence of a selection of eight OXTR gene single nucleotide variants on oxytocin-induced stimulation of human myometrium contractility in vitro.

Methods

Human myometrium biopsies were collected during elective cesarean sections at term, if patients had given informed consent. Myometrial strips were submerged under tension in an organ bath and allowed to contract; the remaining material was stored at - 80 °C for further determination of relevant genetics and

SUBMITTER: Fueg F 

PROVIDER: S-EPMC6852767 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature