Genetic variations in the sheep SIRT7 gene and their correlation with body size traits.

ABSTRACT: As a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase and ADP ribosyl transferase, the silent information regulator 7 (Sirtuin 7, SIRT7) plays a crucial role in regulating the differentiation of adipocytes and myoblasts, lipid metabolism, glucose metabolism, and cellular growth in mammals. It has been hypothesized that SIRT7 affects growth traits in animals; therefore, in this study, the potential insertion/deletion (indel) of genetic variations within the ovine SIRT7 gene and their correlation with sheep growth traits were explored. A total of 709 individuals from five Chinese and Mongolian sheep breeds were analyzed. Two novel indel loci of the sheep SIRT7 gene were detected and were named 5 ' promoter region-insertion-7 bp (5 ' promoter region-7 bp) and 3 ' UTR-inse

SUBMITTER: Xu H 

PROVIDER: S-EPMC6852881 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature