SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies.

ABSTRACT: BACKGROUND:Over the relatively short history of Genome Wide Association Studies (GWASs), hundreds of GWASs have been published and thousands of disease risk-associated SNPs have been identified. Summary statistics from the conducted GWASs are often available and can be used to identify SNP features associated with the level of GWAS statistical significance. Those features could be used to select SNPs from gray zones (SNPs that are nominally significant but do not reach the genome-wide level of significance) for targeted analyses. METHODS:We used summary statistics from recently published breast and lung cancer and scleroderma GWASs to explore the association between the level of the GWAS statistical significance and the expression quantitative trait loci (eQTL) status of the SNP. Data from

SUBMITTER: Gorlov I 

PROVIDER: S-EPMC6852916 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature