Population-specific factors associated with fractional excretion of uric acid.

ABSTRACT:

Background

Reduced renal clearance of uric acid is a major contributor to hyperuricemia. The aim of this study was to examine clinical and genetic variables associated with fractional excretion of uric acid (FEUA).

Methods

Participants (with and without gout) in the Genetics of Gout in Aotearoa study with available genotyping and FEUA data were included (n = 1713). Ten FEUA-associated loci detected within a genome-wide association study for serum urate in a European population were analysed. A polygenic score for FEUA was calculated in each ancestry group to model the cumulative effects of the genetic variants on FEUA. Associations between FEUA and both clinical variables and polygenic score were tested using linear regression models.

Results

The mean (SD) FEUA was 5.

SUBMITTER: Narang RK 

PROVIDER: S-EPMC6852918 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature