MTHFR C677T genetic polymorphism in combination with serum vitamin B₂, B₁₂ and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case-control study.

ABSTRACT:

Background

The study aimed to explore the associations between the interactions of serum vitamin B₂ or B₁₂ levels, aberrant DNA methylation of p16 or p53 and MTHFR C677T polymorphism and the risks of esophageal squamous cell carcinoma (ESCC) and esophageal precancerous lesion (EPL).

Methods

200 ESCC cases, 200 EPL cases and 200 normal controls were matched by age (± 2 years) and gender. Serum vitamin B₂ and B₁₂ levels, MTHFR C677T genetic polymorphisms and the methylation status of genes were assessed. Chi square test, one-way analysis of variance and binary logistic regression were performed.

Results

The lowest quartile of both serum vitamin B₂ and B₁₂ with TT genotype showed significant increased EPL

SUBMITTER: Pan D 

PROVIDER: S-EPMC6852963 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature