Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma.

ABSTRACT:

Background

Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM patients. Given that cancer stem-like cells (CSCs) are roots of metastasis, targeting CSCs may be a promising strategy to overcome hepatic metastasis in UM. Salinomycin, which has been identified as a selective inhibitor of CSCs in multiple types of cancer, may be an attractive agent against CSCs thereby restrain hepatic metastasis in UM. The objective of the study is to explore the antitumor activity of salinomycin against UM and clarify its underlying mechanism.

Methods

UM cells were treated with salinomycin, and its effects on cell proliferation, apoptosis, migration, invasion, CSCs population, and the related signal transducti

SUBMITTER: Zhou J 

PROVIDER: S-EPMC6852970 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature