Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies.

ABSTRACT: Anemia is a common complication of malaria that is characterized by the loss of infected and uninfected erythrocytes. In mouse malaria models, clearance of uninfected erythrocytes is promoted by autoimmune anti-phosphatidylserine (PS) antibodies produced by T-bet⁺B-cells, which bind to exposed PS in erythrocytes, but the mechanism in patients is still unclear. In Plasmodium falciparum patients with anemia, we show that atypical memory FcRL5⁺T-bet⁺ B-cells are expanded and associate both with higher levels of anti-PS antibodies in plasma and with the development of anemia in these patients. No association of anti-PS antibodies or anemia with other B-cell subsets and no association of other antibody specificities with FcRL5⁺T-bet⁺

SUBMITTER: Rivera-Correa J 

PROVIDER: S-EPMC6853636 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature