VulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.

ABSTRACT:

Motivation

Genetic alterations lead to tumor progression and cell survival but also uncover cancer-specific vulnerabilities on gene dependencies that can be therapeutically exploited.

Results

vulcanSpot is a novel computational approach implemented to expand the therapeutic options in cancer beyond known-driver genes unlocking alternative ways to target undruggable genes. The method integrates genome-wide information provided by massive screening experiments to detect genetic vulnerabilities associated to tumors. Then, vulcanSpot prioritizes drugs to target cancer-specific gene dependencies using a weighted scoring system based on well known drug-gene relationships and drug repositioning strategies.

Availability and implementation

http://www.vulcanspot.org.

Supplem

SUBMITTER: Perales-Paton J 

PROVIDER: S-EPMC6853644 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature