A study of circulating microRNAs identifies a new potential biomarker panel to distinguish aggressive prostate cancer.

ABSTRACT: Prostate cancer is one of the most common cancers in men worldwide. Currently available diagnostic and prognostic tools for this disease, such as prostate specific antigen, suffer from lack of specificity and sensitivity, resulting in over- and misdiagnosis. Hence, there is an urgent need for clinically relevant biomarkers capable of distinguishing between aggressive and nonaggressive forms of prostate cancer to aid in stratification, management and therapeutic decisions. To address this unmet need, we investigated the patterns of expression of a panel of 68 plasma-derived microRNAs (miRNAs) in a cohort of African American (AA) and European American (EA) prostate cancer patients (n = 114). miRNA qPCR results were analyzed using in-depth statistical methods, and a bioinformatics analysis wa

SUBMITTER: Farran B 

PROVIDER: S-EPMC6853653 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature