Discovering novel mutation signatures by latent Dirichlet allocation with variational Bayes inference.

ABSTRACT:

Motivation

A cancer genome includes many mutations derived from various mutagens and mutational processes, leading to specific mutation patterns. It is known that each mutational process leads to characteristic mutations, and when a mutational process has preferences for mutations, this situation is called a 'mutation signature.' Identification of mutation signatures is an important task for elucidation of carcinogenic mechanisms. In previous studies, analyses with statistical approaches (e.g. non-negative matrix factorization and latent Dirichlet allocation) revealed a number of mutation signatures. Nonetheless, strictly speaking, these existing approaches employ an ad hoc method or incorrect approximation to estimate the number of mutation signatures, and the whole picture of mut

SUBMITTER: Matsutani T 

PROVIDER: S-EPMC6853711 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature