Local regulation of gene expression by lncRNA promoters, transcription and splicing.

ABSTRACT: Mammalian genomes are pervasively transcribed to produce thousands of long non-coding RNAs (lncRNAs). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA-protein interactions to influence the expression of nearby genes, and it has been suggested that many other lncRNAs can also act as local regulators. Such local functions could explain the observation that lncRNA expression is often correlated with the expression of nearby genes. However, these correlations have been challenging to dissect and could alternatively result from processes that are not mediated by the lncRNA transcripts themselves. For example, some gene promoters have been proposed to have dual functions as enhancers, and the process of transcription itself may contribute to gene regulation by r

SUBMITTER: Engreitz JM 

PROVIDER: S-EPMC6853796 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature