Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease.

ABSTRACT: Echocardiography has become an indispensable tool for the study of heart performance, improving the monitoring of individuals with cardiac diseases. Diverse genetic factors associated with echocardiographic measures have been previously reported. The impact of several apoptotic genes in heart development identified in experimental models prompted us to assess their potential association with human cardiac function. This study aimed at investigating the possible association of variants of apoptotic genes with echocardiographic traits and to identify new genetic markers associated with cardiac function. Genome wide data from different studies were obtained from public repositories. After quality control and imputation, a meta-analysis of individual association study results was performed. Ou

SUBMITTER: Saez ME 

PROVIDER: S-EPMC6853976 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature