In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs.

ABSTRACT: Background: High-dose, pharmacological ascorbate (P-AscH^-) is preferentially cytotoxic to human cancer cells in vitro. Investigations on the efficacy of P-AscH^- as an adjuvant treatment for multiple human cancers are on-going, but has yet to be formally investigated in dogs. The primary objectives of this study were to determine the pharmacokinetic (PK) profile of P-AscH^- in healthy Beagle dogs and the effects of P-AscH^- on canine osteosarcoma cells in vitro. Methods: Eight purpose-bred, healthy, spayed female Beagle dogs, between 20 and 21 months old, and 8-10 kg were administered two doses of P-AscH^- (550 or 2,200 mg/kg) via intravenous infusion over 6 h, on separate days. Plasma ascorbate concentra

SUBMITTER: Musser ML 

PROVIDER: S-EPMC6854015 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature