Shigella flexneri Adherence Factor Expression in In Vivo-Like Conditions.

ABSTRACT: The Shigella species are Gram-negative, facultative intracellular pathogens that invade the colonic epithelium and cause significant diarrheal disease. Despite extensive research on the pathogen, a comprehensive understanding of how Shigella initiates contact with epithelial cells remains unknown. Shigella maintains many of the same Escherichia coli adherence gene operons; however, at least one critical gene component in each operon is currently annotated as a pseudogene in reference genomes. These annotations, coupled with a lack of structures upon microscopic analysis following growth in laboratory media, have led the field to hypothesize that Shigella is unable to produce fimbriae or other traditional adherence factors. Nevertheless, our previous analy

SUBMITTER: Chanin RB 

PROVIDER: S-EPMC6854044 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature