Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition.

ABSTRACT:

Purpose of review

We summarize structural (s)MRI findings of gray matter (GM) atrophy related to cognitive impairment in Alzheimer's disease (AD) and Parkinson's disease (PD) in light of new analytical approaches and recent longitudinal studies results.

Recent findings

The hippocampus-to-cortex ratio seems to be the best sMRI biomarker to discriminate between various AD subtypes, following the spatial distribution of tau pathology, and predict rate of cognitive decline. PD is clinically far more variable than AD, with heterogeneous underlying brain pathology. Novel multivariate approaches have been used to describe patterns of early subcortical and cortical changes that relate to more malignant courses of PD. New emerging analytical approaches that combine structural MRI dat

SUBMITTER: Krajcovicova L 

PROVIDER: S-EPMC6854046 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature