Pharmacotherapy for Cocaine Use Disorder-a Systematic Review and Meta-analysis.

ABSTRACT:

Background

Currently, there are no accepted FDA-approved pharmacotherapies for cocaine use disorder, though numerous medications have been tested in clinical trials. We conducted a systematic review and meta-analysis to better understand the effectiveness of pharmacotherapy for cocaine use disorder.

Methods

We searched multiple data sources (MEDLINE, PsycINFO, and Cochrane Library) through November 2017 for systematic reviews and randomized controlled trials (RCTs) of pharmacological interventions in adults with cocaine use disorder. When possible, we combined the findings of trials with comparable interventions and outcome measures in random-effects meta-analyses. We assessed the risk of bias of individual trials and the strength of evidence for each outcome using standardi

SUBMITTER: Chan B 

PROVIDER: S-EPMC6854210 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature