The Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis: A Meta-Analysis.

ABSTRACT:

Objective

Accumulating evidence indicates that regulatory T cells (Tregs) may be involved in the pathogenesis of ankylosing spondylitis (AS). As different markers have been used to identify Tregs, some studies on the proportions of Tregs in AS patients have generated considerable controversy. To clarify the status of Tregs in such patients, we determine the proportion changes of peripheral Tregs during development of the disease, with different cellular markers.

Methods

We systematically searched Embase, PubMed, Cochrane, Web of Knowledge, FDA.gov, and Clinical Trials.gov for the studies reporting the proportion of Tregs in AS patients. Using the PRISMA guidelines, we performed a random-effects meta-analysis of the frequencies of peripheral Tregs defined in different ways. I

SUBMITTER: Lai NL 

PROVIDER: S-EPMC6854227 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature