Serum Levels of miR-143 Predict Survival in Critically Ill Patients.

ABSTRACT:

Background and aims

Recent data suggested a potential role of miR-143 as a biomarker for systemic inflammation and infection. However, its role in critical illness and sepsis is only poorly understood.

Methods

We determined circulating levels of miR-143 in 218 critically ill patients, of which 135 fulfilled sepsis criteria, and compared them to 76 healthy controls. Results were correlated with clinical records.

Results

In the total cohort of critically ill patients from a medical intensive care unit (ICU), miR-143 serum levels tended to be lower compared to healthy control samples, but this difference did not reach statistical significance. In ICU patients, serum levels of miR-143 were independent of disease etiology, including the presence of sepsis, or severity of d

SUBMITTER: Roderburg C 

PROVIDER: S-EPMC6854254 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature