Syngeneic red blood cell-induced extracellular vesicles suppress delayed-type hypersensitivity to self-antigens in mice.

ABSTRACT:

Background

At present, the role of autologous cells as antigen carriers inducing immune tolerance is appreciated. Accordingly, intravenous administration of haptenated syngeneic mouse red blood cells (sMRBC) leads to hapten-specific suppression of contact hypersensitivity (CHS) in mice, mediated by light chain-coated extracellular vesicles (EVs). Subsequent studies suggested that mice intravenously administered with sMRBC alone may also generate regulatory EVs, revealing the possible self-tolerogenic potential of autologous erythrocytes.

Objectives

The current study investigated the immune effects induced by mere intravenous administration of a high dose of sMRBC in mice.

Methods

The self-tolerogenic potential of EVs was determined in a newly developed mouse model of

SUBMITTER: Nazimek K 

PROVIDER: S-EPMC6854290 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature