Oxidative Stress Impairs Fatty Acid Oxidation and Mitochondrial Function in the Term Placenta.

ABSTRACT: Placental fatty acid oxidation (FAO) is impaired and lipid storage is increased in pregnancy states associated with chronic oxidative stress. The effect of acute oxidative stress, as seen in pregnancies complicated with asthma, on placental lipid metabolism is unknown. We hypothesized that induction of acute oxidative stress would decrease FAO and increase esterification. We assessed [³H]-palmitate oxidation and esterification in term placental explants from lean women after exposure to hydrogen peroxide (H₂O₂) for 4 hours. Fatty acid oxidation decreased 16% and 24% in placental explants exposed to 200 (P = .02) and 400 µM H₂O₂ (P = .01), respectively. Esterification was not altered with H₂O₂ exposur

SUBMITTER: Thomas MM 

PROVIDER: S-EPMC6854426 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature