The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations.

ABSTRACT: Prevotella copri is a common human gut microbe that has been both positively and negatively associated with host health. In a cross-continent meta-analysis exploiting >6,500 metagenomes, we obtained >1,000 genomes and explored the genetic and population structure of P. copri. P. copri encompasses four distinct clades (>10% inter-clade genetic divergence) that we propose constitute the P. copri complex, and all clades were confirmed by isolate sequencing. These clades are nearly ubiquitous and co-present in non-Westernized populations. Genomic analysis showed substantial functional diversity in the complex with notable differences in carbohydrate metabolism, suggesting that multi-generational dietary modifications may be driving reduced prevalence in Westernized populations. Analysis of anc

SUBMITTER: Tett A 

PROVIDER: S-EPMC6854460 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature