MiR‑455 targets FABP4 to protect human endometrial stromal cells from cytotoxicity induced by hydrogen peroxide.

ABSTRACT: Oxidative stress and dysregulation of antioxidant systems are associated with various complications in pregnancy. Endometriosis is a common gynecologic disease that affects women of reproductive age. Recent studies have indicated that oxidative stress may be involved in the pathophysiology of endometriosis. It has been reported that microRNAs can regulate the cellular response to oxidative stress, and mounting evidence indicates that fatty acid binding protein 4 (FABP4) plays an essential role in the regulation of systemic redox capacity. In the present study, we demonstrated that miR‑455 is a putative FABP4‑targeting miRNA. A luciferase activity assay revealed that miR‑455 can successfully bind to the 3'‑UTR of FABP4. Overexpression of miR‑455 led to the downregulation of FABP4 at both th

SUBMITTER: Tang W 

PROVIDER: S-EPMC6854537 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature