Upregulation of miR‑132‑3p in cholangiocarcinoma tissues: A study based on RT‑qPCR, The Cancer Genome Atlas miRNA sequencing, Gene Expression Omnibus microarray data and bioinformatics analyses.

ABSTRACT: MicroRNAs (miRNAs/miRs) have been reported to be closely associated with numerous human diseases, including cholangiocarcinoma (CCA). However, the number of miRNAs known to be involved in CCA is limited, and the association between miR‑132‑3p and CCA remains unknown. In the present study, the clinical role of miR‑132‑3p and its potential signaling pathways were investigated by multiple approaches. Reverse transcription‑quantitative PCR (RT‑qPCR), CCA‑associated Gene Expression Omnibus (GEO), ArrayExpress and Sequence Read Archive (SRA) miRNA‑microarray or miRNA‑sequencing data were screened, and meta‑analyses were conducted, in order to calculate the receiver operating characteristic (ROC) curve and standardized mean difference (SMD). The predicted target genes of miR‑132‑3p were obtained

SUBMITTER: Wu HY 

PROVIDER: S-EPMC6854587 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature