Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice.

ABSTRACT: BACKGROUND:The incidence of dementia and cognitive decline is increasing with no therapy or cure. One of the reasons treatment remains elusive is because there are various pathologies that contribute to age-related cognitive decline. Specifically, with Alzheimer's disease, targeting to reduce amyloid beta plaques and phosphorylated tau aggregates in clinical trials has not yielded results to slow symptomology, suggesting a new approach is needed. Interestingly, exercise has been proposed as a potential therapeutic intervention to improve brain health and reduce the risk for dementia, however the benefits throughout aging are not well understood. RESULTS:To better understand the effects of exercise, we preformed transcriptional profiling on young (1-2 months) and midlife (12 months) C57BL/6

SUBMITTER: Foley KE 

PROVIDER: S-EPMC6854620 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature