Patterns and predictors of failure following tri-modality therapy for locally advanced esophageal cancer.

ABSTRACT:

Background

Although tri-modality therapy is an acceptable standard of care in patients with locally advanced esophageal cancer, data regarding patterns of failure is lacking. We report bi-institutional patterns of failure experience treating patients using tri-modality therapy.

Materials and methods

We retrospectively reviewed patients who underwent chemoradiation followed by esophagectomy between 2006 and 2011 at two NCI-designated cancer centers. First failure sites were categorized as local, regional nodal, or distant. Statistical analysis was performed using Fisher's exact test, non-parametric Wilcoxon rank-sum test, and multiple logistic regression. Kaplan-Meier curves were generated for relapse-free survival (RFS) and overall survival.

Results

A total of 132 pat

SUBMITTER: Shaikh T 

PROVIDER: S-EPMC6854665 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature