Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.

ABSTRACT: BACKGROUND:Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host immunologic response to sepsis is the increase in circulating myeloid-derived suppressor cells (MDSCs), which have been demonstrated to be present and independently associated with poor long-term clinical outcomes. MDSCs are plastic cells and potentially modifiable, particularly through epigenetic interventions. The objective of this study was to determine how the suppressive phenotype of MDSCs evolves after sepsis in surgical ICU patients, as well as to identify epigenetic differences in MDSCs that may explain these changes. METHODS:Circulating MDSCs from 267 survivors of surgical sepsis were phenotyped at various intervals over

SUBMITTER: Hollen MK 

PROVIDER: S-EPMC6854728 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature