The translational network for metabolic disease - from protein interaction to disease co-occurrence.

ABSTRACT:

Background

The recent advances in human disease network have provided insights into establishing the relationships between the genotypes and phenotypes of diseases. In spite of the great progress, it yet remains as only a map of topologies between diseases, but not being able to be a pragmatic diagnostic/prognostic tool in medicine. It can further evolve from a map to a translational tool if it equips with a function of scoring that measures the likelihoods of the association between diseases. Then, a physician, when practicing on a patient, can suggest several diseases that are highly likely to co-occur with a primary disease according to the scores. In this study, we propose a method of implementing 'n-of-1 utility' (n potential diseases of one patient) to human disease network-t

SUBMITTER: Nam Y 

PROVIDER: S-EPMC6854734 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature