The influence of PFK-II overexpression on neuroblastoma patients' survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4.

ABSTRACT:

Background/aim

During cancer progression metabolic reprogramming is observed in parallel to the alternation in transcriptional profiles of malignant cells. Recent studies suggest that metabolic isoenzymes of phosphofructokinase II (PFK-II) - PFKFB3 and PFKFB4, often induced in hypoxic environment, significantly contribute to enhancement of glucose metabolism and in consequence cancer progression.

Materials and methods

Using the publicly available data deposited in the R2 data base we performed a Kaplan-Meyer analysis for cancer patients divided into groups with high and low expression levels of PFKFB3/4, determined based on the median.

Results

Our data showed that high PFKFB3/4 expression significantly correlates with shorter overall survival in several cancers. Moreo

SUBMITTER: Trojan SE 

PROVIDER: S-EPMC6854802 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature