CircGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling.

ABSTRACT:

Background

Circular RNAs (circRNAs), a novel class of noncoding RNAs, have recently drawn much attention in the pathogenesis of human cancers. However, the role of circRNAs in esophageal squamous cell carcinoma (ESCC) remains unclear. In this study, we aimed to identify novel circRNAs that regulate ESCC progression and explored their regulatory mechanisms and clinical significance in ESCC.

Methods

Differentially expressed circRNAs between ESCC and paired adjacent normal tissues were identified using microarrays. The effects of a specific differentially expressed circRNA (circGSK3β) on tumor progression were explored in vitro and in vivo. Plasma samples from patients with ESCC, benign lesions and healthy controls were subjected to droplet digital PCR (ddPCR) analyses for circ

SUBMITTER: Hu X 

PROVIDER: S-EPMC6854808 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature